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HRID2403216

反应详情

EQUATION

反应方程式

HRID 2403216 的结构方程式

REACTANTS

反应物

2
结构：N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccc(F)cc3Cl)CN2)CC1
HCID59543706

未命名化合物

结构：CC1(C)CCCN(C2(C(=O)O)CC2)C1.Cl
HCID86692798

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)CCCN(C2(C(=O)N3C[C@H](S(=O)(=O)c4ccccc4Cl)C[C@H]3C(=O)NC3(C#N)CC3)CC2)C1
HCID71711418

未命名化合物

收率 15%

PROCEDURE

实验过程

The reaction of (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)pyrrolidine-2-carboxamide 7A with 1-(3,3-dimethylpiperidin-1-yl)cyclopropanecarboxylic acid hydrochloride 16M carried out according to the general procedure L yielded (2S,4R)-4-(2-chlorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(1-(3,3-dimethylpiperidin-1-yl)cyclopropanecarbonyl)pyrrolidine-2-carboxamide as a light yellow solid (15%). MS ISP (m/e): 533.3 (100) [(M+H)]+.