Trifluoroacetic acid → HCID 68325566, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 2-(6-(5-chloropyridin-2-ylamino)pyridin-3-yl)morpholine-4-carboxylate (22 mg) in acetonitrile (1.5 ml) and water (4.5 ml) was added trifluoroacetic acid (43 μl). The reaction mixture was then capped and the mixture was shaken at 80° C. for 3 h. The reaction mixture was then cooled to room temperature and poured into EtOAc/THF (1:1) and washed with 1 M aq. NaOH. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash column chromatography (Isolute® Flash-NH2 from Separtis; gradient: heptane/EtOAc/MeOH) to afford (RS)-5-chloro-N-(5-(morpholin-2-yl)pyridin-2-yl)pyridin-2-amine (15 mg, 92%) as a colourless amorphous solid. MS (ISP): 293.1 ([{37Cl}M+H]+), 291.1 ([{35Cl}M+H]+).

Provenance & Evidence