Trifluoroacetic acid → HCID 68325484, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl (RS)-2-(3-chloro-4-(5-cyclopropylpyrimidin-2-ylamino)phenyl)morpholine-4-carboxylate (35 mg) in acetonitrile (1.5 ml) and water (4.5 ml) was added trifluoroacetic acid (77.3 μl). The reaction mixture was then capped and the mixture was shaken at 80° C. for 3 h. The reaction mixture was then cooled to room temperature and poured into EtOAc/THF (1:1) and washed with 1 M aq. NaOH. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash column chromatography (Isolute® Flash-NH2 from Separtis; gradient: heptane/EtOAc/MeOH) to afford (RS)—N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine (28 mg, 76%) as a white solid. MS (ISP): 333.1 ([{37Cl}M+H]+), 331.1 ([{35Cl}M+H]+).

Provenance & Evidence