Hydrochloric Acid → HCID 178516094, compound

Participants

Reaction Steps

The 1-(benzo[d][1,3]dioxol-5-yl)-2-oxo-1,2-dihydroquinoxaline-3-carbonyl chloride thus obtained was dissolved in dichloromethane (30 mL), and the solution was added dropwise to a liquid mixture containing 2.7 g (24 mmol) of 1,3-cyclohexanedione, 3.7 g (36 mmol) of triethylamine and dichloromethane (20 mL), under ice-cooling. After stirring the reaction solution for 3 hours at room temperature, 0.04 g (0.53 mmol) of acetone cyanohydrin and 3.7 g (36 mmol) of triethylamine were added to the liquid mixture, and the mixture was stirred for 12 hours at room temperature. The reaction solution was poured into water, and the aqueous layer was acidified with 10% hydrochloric acid, and extracted with dichloromethane. The obtained organic layer was dried over anhydrous magnesium sulfate, and the inorganic matter was separated by filtration. The solvent was distilled off under reduced pressure, and to the residue thus obtained, a mixed solution of methanol and water was added to obtain a solid. The solid was collected by filtration and dried, to obtain 5.5 g (yield: 75%) of 1-(benzo[d][1,3]dioxol-5-yl)-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-quinoxalin-2(1H)-one as a yellow amorphous matter.

Provenance & Evidence