Hydrochloric Acid → HCID 68325745, compound

Participants

Reaction Conditions

Reaction Steps

(R)-tert-Butyl 2-(4-(6-trifluoromethylpyrimidin-4-ylamino)phenyl)morpholine-4-carboxylate (130 mg, 0.3 mmol) was dissolved in dioxane (1.2 ml) and a solution of HCl in dioxane (4 M, 1.15 ml, 4.59 mmol) was added. The reaction mixture was stirred at 60° C. for 2 hours. After cooling ether (2 ml) was added and the solid was filtered off. It was washed with ether and dried in vacuo to afford (R)—N-(4-(morpholin-2-yl)phenyl)-6-(trifluoromethyl)pyrimidin-4-amine hydrochloride (96 mg, 87%) as a light yellow solid. MS (ISP): 325.2 ([M+H]+).

Provenance & Evidence