HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Formylphenylboronic acid → HCID 86619249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Formylphenylboronic acid | HCID 2734356 | — |
| Reactant | 2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine | HCID 56833946 | — |
| Product | HCID 86619249 | HCID 86619249 | — |
Reaction Steps
2-Chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine was reacted with 3-formylphenylboronic acid in General Procedure A to yield 3-[6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidin-2-yl]-benzaldehyde. Treatment of this aldehyde with sodium borohydride (2.5 equivalents) in ethanol yielded the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802670B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-fb9ea441fa3e4d90a08560197243fbd7 |
| Source note | uspto-grants-2014_08 |