4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → HCID 46180663, compound

Participants

Reaction Steps

2-Chloro-6-(4-methylsulfonyl-piperazine-1-yl-methyl)-4-morpholin-4-yl-thieno[3,2-d}pyrimidine was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline in General Procedure A. Purification on silica yielded 4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl]-aniline. This was then reacted with acetic anhydride in dichloromethane and triethylamine to give the desired compound.

Provenance & Evidence