HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 46739418, compound → HCID 66617765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 46739418 | HCID 46739418 | — |
| Reactant | 4-(2-Chloro-6-((4-methylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 57420338 | — |
| Product | HCID 66617765 | HCID 66617765 | — |
Reaction Steps
2-Chloro-6-(4-methyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 3-(4-methoxy-benzyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine in General Procedure A. Purification on silica yielded 2-[5-(4-methoxy-benzyloxy)-pyridin-3-yl]-6-(4-methyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine. This was then reacted with trifluoroacetic acid in dichloromethane to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802670B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b98dfe074bf54e418e3b298a85490c2d |
| Source note | uspto-grants-2014_08 |