1-(Isopropylsulfonyl)piperazine → 2-Chloro-4-morpholin-4-yl-6-[4-(propane-2-sulfonyl)-piperazin-1-ylmethyl]-thieno[3,2-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	1-(Isopropylsulfonyl)piperazine	HCID 22562851	—
Reactant	2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde	HCID 45789985	—
Product	2-Chloro-4-morpholin-4-yl-6-[4-(propane-2-sulfonyl)-piperazin-1-ylmethyl]-thieno[3,2-d]pyrimidine	HCID 86619254	—

Reaction Steps

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-(propane-2-sulfonyl)-piperazine using procedure C yielded 2-chloro-4-morpholin-4-yl-6-[4-(propane-2-sulfonyl)-piperazin-1-ylmethyl]-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08802670B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-0444aff087274c25bda2f601dea3f11b
Source note	uspto-grants-2014_08