2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → HCID 86619258, compound

HRID 2403402Notes

Reaction equation

HRID 2403402 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.Cl.[CH3:20][S:21]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][C:25]1([CH3:31])[CH3:30])(=[O:23])=[O:22]>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:27]3[CH2:28][CH2:29][N:24]([S:21]([CH3:20])(=[O:22])=[O:23])[C:25]([CH3:31])([CH3:30])[CH2:26]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehydeHCID 66617877HCID 66617877, compound

Product 1

HCID 86619258HCID 86619258, compound

Procedure

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-methanesulfonyl-2,2-dimethyl-piperazine hydrochloride salt using procedure C yielded 2-chloro-6-(4-methanesulfonyl-3,3-dimethyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography.

Sources & evidence

ORD record
ord-0ed03a7aa19a4f8cadb4b86e193313f2
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

Loading…