HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 86619262, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | N-(2-methoxyethyl)-1-methylpiperidin-4-amine | HCID 2761027 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde | HCID 45789985 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 86619262 | HCID 86619262 | 41.7% |
Reaction Steps
2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde (150 mg) and (2-methoxy-ethyl)-(1-methyl-piperidin-4-yl)-amine (128 mg) were stirred together in 1,2-dichloroethane (8 ml) and acetic acid (32 mg) with sodium triacetoxyborohydride (146 mg) at room temperature overnight. Dichloromethane/aqueous sodium hydrogen carbonate extraction and purification on silica yielded (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-(2-methoxy-ethyl)-(1-methyl-piperidin-4-yl)-amine (97 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802670B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-768953e5ab3d4e24b7463f0baf723a88 |
| Source note | uspto-grants-2014_08 |