Sodium Hydroxide → HCID 57494065, compound

Participants

Reaction Steps

To a suspension of piperazine-2-carboxylic acid dihydrochloride (10 g) in 1,4-dioxane (100 mL) and water (50 mL) at 0° C. was added 17M NaOH solution in portions followed by di-tert-butyldicarbonate (11.8 g). The resulting mixture was warmed to R.T. and stirred for 5 h. Triethylamine (13.7 mL) and methanesulfonyl chloride (3.8 mL) were added this mixture was stirred overnight at R.T. The reaction mixture was concentrated in vacuo, diluted with 2M HCl and extracted with EtOAC. Combined extracts were dried (MgSO4), filtered and concentrated to give 4-methanesulfonyl-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (8.46 g).

Provenance & Evidence