HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403431Generated: November 1, 2026
Potassium Carbonate → HCID 86619268, compound
https://huagongshe.com/reaction/2403431
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 46180726 | — |
| Reactant | HCID 66617770 | HCID 66617770 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86619268 | HCID 86619268 | 58.6% |
Reaction Steps
To a mixture of 6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (140 mg) and (1-methanesulfonyl-piperazin-2-ylmethyl)-dimethyl-amine dihydrochloride (140 mg) in dry MeCN (6 mL) was added K2CO3 (190 mg). The mixture was stirred at 80° C. for 4 h. An aqueous work-up followed by purification on silica gave [4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1-methanesulfonyl-piperazin-2-ylmethyl]-dimethyl-amine (115 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08802670B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-17479cad8a484805a5eab433ff881b52 |
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| Source note | uspto-grants-2014_08 |
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