Methanesulfonyl chloride → 1,1-Dimethylethyl hexahydro-4-(methylsulfonyl)-1H-1,4-diazepine-1-carboxylate

Participants

Reaction Steps

To 1-BOC-homopiperazine (0.8 ml) was added methane sulphonyl chloride (0.34 ml) and triethylamine (0.68 ml). The reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was then partitioned between dichloromethane and water. The combined organic extracts were then washed with brine and dried (MgSO4). The solvent was removed in vacuo to yield 1.23 g of crude 4-methanesulfonyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester.

Provenance & Evidence