Diethyl Ether → HCID 131731751, compound

Participants

Reaction Steps

A mixture of 2.5 g (15.9 mmol) of 3-(1,1-difluoroethyl)aniline and 2.8 g (15.9 mmol) of bis(2-chloroethyl)amine in 20 mL of chlorobenzene is refluxed overnight. After cooling to room temperature, diethyl ether is added and precipitation occurs. The solid is filtered, washed with diethyl ether and dried under reduced pressure to give 3.8 g (90%) of 1-[3-(1,1-difluoro-ethyl)phenyl]piperazine, hydrochloride as a white solid.

Provenance & Evidence