Dimethyl Sulfoxide → HCID 68811711, compound

Participants

Reaction Steps

A mixture of 85 mg (0.2 mmol) of N-(4-{2-[4-(3-cyanophenyl)piperazin-1-yl]ethyl}cyclohexyl)-4-methoxybutanamide, 2 mL of dimethyl sulfoxide, 16.5 mg of potassium carbonate and 0.12 mL of an aqueous 30% hydrogen peroxyde solution is stirred for 2 hours at room temperature. The suspension is poured into 50 mL of water. The solid is filtered, washed with water, dried under reduced pressure to give 15 mg (17%) of 3-(4-{2-[4-(4-methoxybutanylamino)cyclohexyl]ethyl}piperazin-1-yl)benzamide as a white solid.

Provenance & Evidence