HCID 70570435, compound → HCID 68106724, compound

Participants

Reaction Steps

Ethyl (2E)-3-[6-(4-{5-[3-({[N-(tert-butoxycarbonyl)glycyl](methyl)amino}methyl)phenyl]pyrimidin-2-yl}piperazin-1-yl)-5-methylpyridin-3-yl]acrylate (250 mg) was dissolved in EtOH (4 ml), and 10% Pd/C (80 mg) was added thereto under a hydrogen atmosphere at 1 atm, followed by stirring at room temperature overnight. The mixture was filtrated using Celite as a filtration assistant to remove the catalyst, and then the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/EtOAc) to obtain ethyl 3-[6-(4-{5-[3-({[N-(tert-butoxycarbonyl)glycyl](methyl)amino}methyl)phenyl]pyrimidin-2-yl}piperazin-1-yl)-5-methylpyridin-3-yl]propanoate (163 mg).

Provenance & Evidence