Lithium hydroxide, monohydrate → HCID 70896144, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-(methylcarbamoyl)-1H-indazole-5-carboxylate (400 mg, 1.7 mmol) in methanol (10 mL) and water (10 mL), was added lithium hydroxide monohydrate (0.36 g, 8.5 mmol). The reaction was heated to 60° C. and was stirred overnight. The methanol was removed under reduced pressure and the remaining residue was acidified to pH=4 with 1 N aqueous hydrochloric acid. The resulting precipitate was collected by filtration and dried under vacuum to give the title compound (350 mg, 94%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6, δ): 13.99 (s, 1 H), 8.85 (s, 1 H), 8.47-8.48 (m, 1 H), 7.94-7.96 (m, 1 H), 7.65-7.68 (m, 1 H), 2.82 (d, J=4.4 Hz, 3 H).

Provenance & Evidence