2-tert-butyl-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(2H)-one hydrochloride salt → Tert-butyl 2-(3-(2-tert-butyl-7-oxo-2,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-ylcarbonyl)quinolin-6-yloxy)acetate

Participants

Reaction Steps

The title compound was prepared by a method analogous to that described for Example 3, using 6-(2-tert-butoxy-2-oxoethoxy)quinoline-3-carboxylic acid and 2-tert-butyl-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(2H)-one hydrochloride salt. +ESI (M+H) 547.3; 1H NMR (400 MHz, CDCl3, δ): 8.77 (d, J=2.0 Hz, 1 H), 8.10 (d, J=1.6 Hz, 1 H), 8.06 (d, J=9.2 Hz, 1 H), 7.50 (dd, J=9.3, 2.8 Hz, 1 H), 7.41 (s, 1 H), 7.02 (d, J=2.7 Hz, 1 H), 4.64 (s, 2 H),3.68-3.93 (m, 2 H), 3.41-3.51 (m, 2 H), 2.78 (s, 2 H), 2.65 (s, 2 H), 1.53-1.76 (m, 4 H), 1.61 (s, 9 H), 1.49 (s, 9 H).

Provenance & Evidence