1H-Indazole-5-carboxylic acid → HCID 70896166, compound

HRID 2403706Notes

Reaction equation

HRID 2403706 reaction equation
[C:1]12([N:6]3[CH:19]=[C:18]4[C:8]([C:9](=[O:20])[CH2:10][C:11]5([CH2:17]4)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]5)=[N:7]3)[CH2:5][CH:3]([CH2:4]1)[CH2:2]2.[NH:21]1[C:29]2[C:24](=[CH:25][C:26]([C:30](O)=[O:31])=[CH:27][CH:28]=2)[CH:23]=[N:22]1>>[C:1]12([N:6]3[CH:19]=[C:18]4[C:8]([C:9](=[O:20])[CH2:10][C:11]5([CH2:17]4)[CH2:16][CH2:15][N:14]([C:30]([C:26]4[CH:25]=[C:24]6[C:29](=[CH:28][CH:27]=4)[NH:21][N:22]=[CH:23]6)=[O:31])[CH2:13][CH2:12]5)=[N:7]3)[CH2:4][CH:3]([CH2:2]1)[CH2:5]2

Participants

3

Reactant 2

HCID 42484541H-Indazole-5-carboxylic acidHCID 70896057HCID 70896057, compound

Product 1

HCID 70896166HCID 70896166, compound

Procedure

The title compound was prepared by a method analogous to that described in Example 1, using 2-(bicyclo[1.1.1]pentan-1-yl)-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(2H)-one and 1H-indazole-5-carboxylic acid. +ESI (M+H) 416.2; HPLC retention time 2.32 minutes (Method A).

Sources & evidence

ORD record
ord-cc6e897a7e9d4796b62a5621dca2885a
Source dataset
uspto-grants-2014_08
Patent number
US08802688B2

Reaction notes

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