Potassium Carbonate → 1251017-66-9

HRID 2403707노트

반응식

HRID 2403707 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]2[CH2:14][CH:10]([N:11]2C(C(F)(F)F)=O)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH:10]2[CH2:14][CH:12]([NH:11]2)[CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 86674329HCID 86674329, 화합물

생성물 1

HCID 509864141251017-66-9수율 79%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 3-(tert-butoxycarbonyl)-6-(trifluoromethylcarbonyl)-3,6-diazabicyclo[3.1.1]heptane (4) (8.5 g, 28.9 mmol) and potassium carbonate (30.7 g, 2 eq, 57.8 mmol) in methanol (150 mL) was heated at 70° C. for 3 h. The solution was cooled to ambient temperature and the solvent was removed in vacuo. The crude material was dissolved in a 1:1 solution of methylene chloride:methanol and filtered to give 3-(tert-butoxycarbonyl)-3,6-diazabicyclo[3.1.1]heptane (5) (4.5 g, 79% yield) as an off-white solid.

후처리

  1. customthe solvent was removed in vacuo
  2. dissolutionThe crude material was dissolved in a 1:1 solution of methylene chloride
  3. filtrationmethanol and filtered

출처 및 근거

ORD 기록
ord-03dd8fec9f984241be1501259bbae137
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08802694B2

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