Phenylmethyl 3-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate → 2-(Butyloxy)-8-(methyloxy)-9-[3-(3-piperidinyl)propyl]-9H-purin-6-amine

HRID 2403823Notes

Reaction equation

HRID 2403823 reaction equation
C(OC1N=C2C(N=C(OC)N2CCCC2CCCCN2)=C(N)N=1)CCC.[NH2:27][C:28]1[N:36]=[C:35]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[N:34]=[C:33]2[C:29]=1[N:30]=[C:31]([O:61][CH3:62])[N:32]2[CH2:42][CH2:43][CH2:44][CH:45]1[CH2:50][CH2:49][CH2:48][N:47](C(OCC2C=CC=CC=2)=O)[CH2:46]1>>[CH2:38]([O:37][C:35]1[N:34]=[C:33]2[C:29]([N:30]=[C:31]([O:61][CH3:62])[N:32]2[CH2:42][CH2:43][CH2:44][CH:45]2[CH2:50][CH2:49][CH2:48][NH:47][CH2:46]2)=[C:28]([NH2:27])[N:36]=1)[CH2:39][CH2:40][CH3:41]

Participants

3

Reactant 2

HCID 58306094Phenylmethyl 3-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 583061842-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine

Product 1

HCID 583061302-(Butyloxy)-8-(methyloxy)-9-[3-(3-piperidinyl)propyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 32 from phenylmethyl 3-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate.

Sources & evidence

ORD record
ord-241b0ef7b34a4e97a9628d055fcaa3aa
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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