Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403843Generated: November 2, 2026

Benzyl 4-(bromomethyl)piperidine-1-carboxylate → Phenylmethyl 4-{[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]methyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/2403843

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 4-(bromomethyl)piperidine-1-carboxylateHCID 2776274—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178448286HCID 178448286—
ProductPhenylmethyl 4-{[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]methyl}-1-piperidinecarboxylateHCID 58306118—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate salt and phenylmethyl 4-(bromomethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08802684B2
Source datasetuspto-grants-2014_08
ORD IDord-297b958e20e74ce88eb15a7ba914e19c
Source noteuspto-grants-2014_08