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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403849Generated: October 30, 2026

Benzyl 4-(2-bromoethyl)piperidine-1-carboxylate → Phenylmethyl 4-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/2403849

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 4-(2-bromoethyl)piperidine-1-carboxylateHCID 11056468—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178448286HCID 178448286—
ProductPhenylmethyl 4-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 58306076—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate salt and phenylmethyl 4-(2-bromoethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08802684B2
Source datasetuspto-grants-2014_08
ORD IDord-c23a4e5a849544b58f54eea0130f0ef5
Source noteuspto-grants-2014_08