Isopropyl iodide → 2-{[(1S)-1-Methylbutyl]oxy}-9-{2-[1-(1-methylethyl)-4-piperidinyl]ethyl}-8-(methyloxy)-9H-purin-6-amine

HRID 2403852Notes

Reaction equation

HRID 2403852 reaction equation
C(N1CC[CH2:6][CH:5](CCN2C(OC)=NC3C2=NC(O[C@@H](C)CCC)=NC=3N)[CH2:4]1)C.[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:52][CH3:53])[N:41]2[CH2:44][CH2:45][CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)=[C:37]([NH2:54])[N:36]=1)[CH2:31][CH2:32][CH3:33].IC(C)C>>[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:52][CH3:53])[N:41]2[CH2:44][CH2:45][CH:46]2[CH2:47][CH2:48][N:49]([CH:5]([CH3:6])[CH3:4])[CH2:50][CH2:51]2)=[C:37]([NH2:54])[N:36]=1)[CH2:31][CH2:32][CH3:33]

Participants

4

Procedure

Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine and 2-iodopropane.

Sources & evidence

ORD record
ord-f4babab399c64cd09c39ca7afd86682f
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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