Isopropyl iodide → 2-{[(1S)-1-Methylbutyl]oxy}-9-{3-[1-(1-methylethyl)-4-piperidinyl]propyl}-8-(methyloxy)-9H-purin-6-amine
Reaction equation
C(N1CC[CH2:6][CH:5](CCN2C(OC)=NC3C2=NC(O[C@@H](C)CCC)=NC=3N)[CH2:4]1)C.[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:53][CH3:54])[N:41]2[CH2:44][CH2:45][CH2:46][CH:47]2[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)=[C:37]([NH2:55])[N:36]=1)[CH2:31][CH2:32][CH3:33].IC(C)C>>[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:53][CH3:54])[N:41]2[CH2:44][CH2:45][CH2:46][CH:47]2[CH2:52][CH2:51][N:50]([CH:5]([CH3:6])[CH3:4])[CH2:49][CH2:48]2)=[C:37]([NH2:55])[N:36]=1)[CH2:31][CH2:32][CH3:33]Participants
4
Reactant 3
Product 1
Procedure
Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[3-(4-piperidinyl)propyl]-9H-purin-6-amine and 2-iodopropane.
Sources & evidence
- ORD record
- ord-08b89e0c98bf467ebfb51b5ce5329ae1
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08802684B2
Reaction notes
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