Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate → Phenylmethyl 4-{6-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]hexyl}-1-piperidinecarboxylate

HRID 2403873Notes

Reaction equation

HRID 2403873 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:35][CH3:36])[N:6]2[CH2:16][CH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21]N1C(OCC1C=CC=CC=1)=O.FC(F)(F)C(O)=O.C(OC1N=C2C(N=C(OC)N2)=C(N)N=1)CCC.BrCCCCCCC1C[CH2:72][N:71]([C:74]([O:76][CH2:77][C:78]2[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=2)=[O:75])[CH2:70][CH2:69]1>>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:35][CH3:36])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:24][CH2:23][CH:22]1[CH2:21][CH2:72][N:71]([C:74]([O:76][CH2:77][C:78]2[CH:79]=[CH:80][CH:81]=[CH:82][CH:83]=2)=[O:75])[CH2:70][CH2:69]1

Participants

4

Reactant 3

HCID 58306132Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306218Phenylmethyl 4-(6-bromohexyl)-1-piperidinecarboxylateHCID 178450370HCID 178450370, compound

Product 1

HCID 58306220Phenylmethyl 4-{6-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]hexyl}-1-piperidinecarboxylate

Procedure

Prepared similarly to Intermediate 31 from 2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine trifluoroacetate and phenylmethyl 4-(6-bromohexyl)-1-piperidinecarboxylate.

Sources & evidence

ORD record
ord-bc5f2ce36f974864a4ef3ffd08a1f159
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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