Hydrochloric Acid → HCID 67182077, compound

Participants

Reaction Steps

The crude aqueous solution containing approx 45 mg 2-(butyloxy)-8-(methyloxy)-9-[2-(2-piperidinyl)ethyl]-9H-purin-6-amine (45 mg, 0.129 mmol) was treated with a solution of HCl in 1,4-dioxane (0.807 mL, 3.23 mmol, 4 molar solution). This was stirred at ambient temperature in a capped vial overnight to give a pale solution. A further 1 ml of 4 molar HCl solution in 1,4-dioxane was added and stirring continued over the weekend. The yellow reaction solution was evaporated to dryness under N2 in a blow down unit. The residue was purified by MDAP (Method A), appropriate fractions were evaporated under N2 in a blow down unit to give the title compound as a white solid (23.3 mg).

Provenance & Evidence