Iodocyclopentane → 6-Amino-2-(butyloxy)-9-[3-(1-cyclopentyl-3-piperidinyl)propyl]-7,9-dihydro-8H-purin-8-one

HRID 2403918Notes

Reaction equation

HRID 2403918 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][NH:20][CH2:19]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][N:20]([CH:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:19]1

Participants

3

Reactant 2

HCID 73784IodocyclopentaneHCID 583061302-(Butyloxy)-8-(methyloxy)-9-[3-(3-piperidinyl)propyl]-9H-purin-6-amine

Product 1

HCID 671811296-Amino-2-(butyloxy)-9-[3-(1-cyclopentyl-3-piperidinyl)propyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[3-(3-piperidinyl)propyl]-9H-purin-6-amine and iodocyclopentane.

Sources & evidence

ORD record
ord-82e738dde81d4cc480efa8e09f2e9e1b
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

Loading…