3-Bromopentane → 6-Amino-2-(butyloxy)-9-{2-[1-(1-ethylpropyl)-4-piperidinyl]ethyl}-7,9-dihydro-8H-purin-8-one

HRID 2403936Notes

Reaction equation

HRID 2403936 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Br[CH:27]([CH2:30][CH3:31])[CH2:28][CH3:29]>>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:18][CH2:19][N:20]([CH:27]([CH2:30][CH3:31])[CH2:28][CH3:29])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 157383-BromopentaneHCID 583062442-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 672335736-Amino-2-(butyloxy)-9-{2-[1-(1-ethylpropyl)-4-piperidinyl]ethyl}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 80 from 2-(butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine and 3-bromopentane.

Sources & evidence

ORD record
ord-098d9abe5c5140c8ae1d3f6d615b5749
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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