Iodocyclohexane → 6-Amino-2-(butyloxy)-9-[2-(1-cyclopentyl-4-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

HRID 2403938Notes

Reaction equation

HRID 2403938 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29]C1>>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:18][CH2:19][N:20]([CH:29]2[CH2:30][CH2:31][CH2:32][CH2:27]2)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 12289IodocyclohexaneHCID 583062442-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 671812436-Amino-2-(butyloxy)-9-[2-(1-cyclopentyl-4-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 80 from 2-(butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine and iodocyclohexane.

Sources & evidence

ORD record
ord-e33bc3252cde461ab9e813d33d447c38
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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