Diclofensine → Tartrate

Participants

Role	Name	HCID	Charge
Reactant	Diclofensine	HCID 68871	—
Reactant	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—
Product	Tartrate	HCID 119400	—
Product	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—

Reaction Steps

The L-tartrate of the (−)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline was prepared using (−)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline following similar steps described for the synthesis of the (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-tartrate salt ([α]24D-6.0° (c 0.10, methanol)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08802696B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-080f4c0bf0ee482c9143365b7c1908a0
Source note	uspto-grants-2014_08