Water → 2,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

Participants

Reaction Steps

A solution of N-methylethylenediamine (27.0 g, 364.0 mmol) and ethyl trifluoroacetate (96.6 ml, 838.0 mmol) in a mixture of acetonitrile (350 ml) and water (7.8 ml, 436 mmol) was refluxed overnight with stirring. Next the solvents were evaporated in vacuo. Residue was re-evaporated with isopropanol (3×100 ml). Residue was dissolved in dichloromethane (500 ml) and left overnight at room temperature. The formed crystals were filtered, washed with dichloromethane and dried in vacuo to provide compound A (96.8 g, 94%) as white solid powder.

Provenance & Evidence