反应详情

Compound D (4.14 g, 5.77 mmol) and AcOH (330 μl, 5.77 mmol) was dissolved in methanol (40 ml) followed by the addition of Pd/C (5% wt, 880 mg) suspension in water (5 ml). The reaction mixture was subjected to hydrogenation (Parr apparatus, 75 psi) at room temperature for 2.5 h. The catalyst was filtered over a pad of Celite on sintered glass funnel and washed with methanol. Filtrate was evaporated in vacuo to provide compound E (1.96 g, 3.2 mmol) as yellowish amorphous solid. LC-MS [M+H] 483.2 (C22H38N6O4S+H, calc: 483.2).

1. filtrationThe catalyst was filtered over a pad of Celite on sintered glass funnel
2. washwashed with methanol
3. customFiltrate was evaporated in vacuo