Acetic Anhydride → HCID 67443497, compound

Participants

Reaction Steps

To a solution of compound H (1.4 g, 3.21 mmol) in CHCl3 (10 mL) at room temperature was added DIEA (2.6 mL, 15 mmol) followed by Ac2O (0.85 mL, 9.0 mmol). The reaction mixture was stirred at room temperature for 2 h. Solvents were removed in vacuo and then the residue was dissolved in dichloromethane (100 mL). The organic layer was washed with 10% citric acid (75 mL), saturated NaHCO3 (75 mL) and brine (75 mL). The organic layer was separated, dried over Na2SO4 and solvent removed in vacuo to afford compound I (1.45 g, 99%). LC-MS [M+H] 479.5 (C24H38N4O6+H, calc: 479.5).

Provenance & Evidence