HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(Methylamino)-2-(methylthio)pyrimidin-5-yl)methanol | HCID 10679092 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | HCID 10607520 | 91.3% |
Reaction Steps
A suspension of (4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methanol (3.1 g, 16.73 mmol) and manganese dioxide (7.27 g, 83.67 mmol) in DCM (40 mL) was stirred at room temperature for 12 hours. The resulting precipitate was filtered off, and the filtrate was concentrated to give 4-(methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde (2.8 g, 91%) as a yellowish solid. MS (ES+) C7H9N3OS requires: 183. found: 184 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802697B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-77be44073452485599df9c5a80764a08 |
| Source note | uspto-grants-2014_08 |