2-Chloro-N4-methylpyrimidine-4,5-diamine → 2-chloro-6-(3,5-dimethoxyphenyl)-8-methylpteridin-7(8H)-one

참여 물질

역할	이름	HCID	투입량
반응물	2-Chloro-N4-methylpyrimidine-4,5-diamine	HCID 7147172	—
반응물	Ethyl (3,5-dimethoxyphenyl)(oxo)acetate	HCID 24722256	—
용매	Acetic Acid	HCID 176	—
용매	Ethanol	HCID 702	—
용매	Dichloromethane	HCID 6344	—
생성물	2-chloro-6-(3,5-dimethoxyphenyl)-8-methylpteridin-7(8H)-one	HCID 86713572	55.4%

반응 조건

온도	80 °C

반응 단계

A mixture of ethyl 2-(3,5-dimethoxyphenyl)-2-oxoacetate (1 g, 4.2 mmol) and 2-chloro-N4-methylpyrimidine-4,5-diamine (600 mg, 3.8 mmol) in ethanol (100 mL) and acetic acid (2.5 mL) was stirred at 80° C. for 48 h and cooled to RT (5° C.). The mixture was diluted with dichloromethane and washed with brine. The organic layer was directly concentrated and purified by chromatography on silica gel to give the title compound (700 mg, 50%). MS (ES+) C15H13ClN4O3 requires: 332, 334. found: 333, 335 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08802697B2
출처 데이터셋	uspto-grants-2014_08
ORD ID	ord-15ecb518e3ba44c280e7db32c35f7a6a
출처 메모	uspto-grants-2014_08