Sodium Carbonate → HCID 71547489, compound

Participants

Reaction Conditions

Reaction Steps

To (7S,8aS)-tert-butyl 7-aminohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (310 mg, 1.29 mmol) and sodium carbonate (0.26 g, 2.5 mmol) in dimethyl sulfoxide (1 mL) was added 2-chloro-6-(trifluoromethyl)pyridine (0.35 g, 1.93 mmol). The mixture was stirred at 100° C. for 3 days and then concentrated. The residue was purified by chromatography on silica gel (100% ethyl acetate) to provide the title compound. MS (ESI) m/z 387 (M+H)+.

Provenance & Evidence