4-Bromo-2-methyl-quinolin-6-ol → HCID 178422415, compound

HRID 2404160Notes

Reaction equation

HRID 2404160 reaction equation
[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[N:18]=[C:17]([CH3:22])[CH:16]=[C:15]3C(F)(F)F)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[Br:27]C1C2C(=CC=C(O)C=2)N=C(C)C=1>>[Br:27][C:15]1[C:14]2[C:19](=[CH:20][CH:21]=[C:12]([O:11][C@H:8]3[CH2:9][CH2:10][C@H:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:6][CH2:7]3)[CH:13]=2)[N:18]=[C:17]([CH3:22])[CH:16]=1

Participants

3

Reactant 2

HCID 669264634-Bromo-2-methyl-quinolin-6-olHCID 178426037HCID 178426037, compound

Product 1

HCID 178422415HCID 178422415, compound

Procedure

Synthesized as per 6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline using 4-Bromo-2-methyl-quinolin-6-ol as starting material. ESI-MS (M+H+): 378.1.

Sources & evidence

ORD record
ord-bc687398387947aca6d1be64ee29f0d2
Source dataset
uspto-grants-2014_08
Patent number
US08802659B2

Reaction notes

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