HCID 178445806, compound → HCID 178498767, compound

HRID 2404162Notes

Reaction equation

[CH3:1][O:2][C:3]([CH:5]1[CH2:8][N:7]([CH2:9][C:10]2[CH:19]=[C:18](C(F)(F)F)[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:24][C@H:25]4[CH2:30][CH2:29][C@H:28]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH2:27][CH2:26]4)[CH:16]=3)[N:11]=2)[CH2:6]1)=[O:4].[Br:35]C1C2C(=CC=C(O[C@H]3CC[C@H](C(C)(C)C)CC3)C=2)N=C(C=O)C=1>>[CH3:1][O:2][C:3]([CH:5]1[CH2:8][N:7]([CH2:9][C:10]2[CH:19]=[C:18]([Br:35])[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:24][C@H:25]4[CH2:30][CH2:29][C@H:28]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH2:27][CH2:26]4)[CH:16]=3)[N:11]=2)[CH2:6]1)=[O:4]

Participants

Reactant 2

HCID 178445806HCID 178445806, compound

HCID 178498779HCID 178498779, compound

Product 1

HCID 178498767HCID 178498767, compound

Procedure

Synthesized as per 1-[6-(trans-4-tert-Butyl-cyclohexyloxy)-4-trifluoromethyl-quinolin-2-ylmethyl]-azetidine-3-carboxylic acid methyl ester using 4-Bromo-6-(trans-4-tert-butyl-cyclohexyloxy)-quinoline-2-carbaldehyde as starting material. ESI-MS (M+H+): 489.20/491.20.

Sources & evidence

ORD record: ord-d8e2d7b7bef240598fcf00ad72110273
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08802659B2

Reaction notes

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