反应详情

7,8-Dimethoxy-3H-pyrazolo[3,4-c]quinoline (500 mg, 2.18 mmol) is dissolved in water (40 ml). Bromine (220 μl, 4.36 mmol) is subsequently added dropwise at room temperature with exclusion of light. The reaction solution is then stirred for 1 h. When the reaction is complete, the mixture is evaporated to dryness in vacuo, giving 1-bromo-7,8-dimethoxy-3H-pyrazolo[3,4-c]quinoline (752 mg, purity 85%, 2.07 mmol) as a solid. MS: 308.0/310.0 (M+H+, monobromo isotope distribution), TLC (HPTLC): Rf=0.50 (ethyl acetate/ethanol 8:1, parts by volume).

1. customthe mixture is evaporated to dryness in vacuo