Methyl iodide → HCID 66632686, compound

Participants

Reaction Steps

4-(7,8-Dimethoxy-3H-pyrazolo[3,4-c]quinolin-1-yl)-2-hydroxymethylbenzonitrile (78 mg, 216 μmol) is dissolved in N,N-dimethylformamide (1.0 ml) under argon, and methyl iodide (34 μl, 541 μmol) and potassium carbonate (60 mg, 433 μmol) are subsequently added. The suspension is stirred at room temperature for 1 h. For purification, the mixture is extracted with ethyl acetate and semi-saturated sodium chloride solution. The organic phase is dried over Na2SO4, filtered with suction and evaporated to dryness in vacuo. The residue is purified by chromatography (pHPLC, solvent gradient water/1-30% by vol. of acetonitrile, 0.1% by vol. of formic acid), and the product fractions are lyophilised, giving 4-(7,8-dimethoxy-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)-2-hydroxymethylbenzonitrile (41 mg, 110 μmol) as a solid. MS: 375.2 (M+H+).

Provenance & Evidence