HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)benzonitrile → tert-Butyl (4-cyanobenzyl)glycinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | Glycine tert-butyl ester | HCID 151417 | — |
| Product | tert-Butyl (4-cyanobenzyl)glycinate | HCID 18000198 | — |
Reaction Steps
The title compound was prepared following the general procedure 10, starting from 4-cyanobenzyl bromide and tert-butyl glycinate. It was isolated as a colorless oil. 1H NMR (DMSO-d6, 300 MHz) δ 7.78 (d, J=8.3 Hz, 2H), 7.52 (d, J=8.3 Hz, 2H), 3.79 (s, 2H), 3.19 (s, 2H), 2.60 (br s, 1H), 1.41 (s, 9H). HPLC (Method A) Rt 2.17 min (Purity: 97.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802704B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-6dce9f10a81f46569a8b638fc1d45c19 |
| Source note | uspto-grants-2014_08 |