反应详情

A mixture of tert-butyl N-(4-cyano-2-vinylbenzyl)-N-methylglycinate (500 mg, 1.75 mmol) and 10% palladium on carbon (50 mg) in methanol (5 mL) were stirred under an atmosphere of hydrogen for 18 hours. The suspension was filtered through a Celite pad and the filter-cake washed with DCM. The filtrate was evaporated in vacuo to afford the title compound (474 mg, 94%).

1. filtrationThe suspension was filtered through a Celite pad
2. washthe filter-cake washed with DCM
3. customThe filtrate was evaporated in vacuo