Benzoyl Peroxide → HCID 66677293, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-methyl-3-chlorobenzonitrile (4.69 g, 31 mmol), N-bromosuccinimide (6.04 g, 34.2 mmol) and benzoyl peroxide (0.750 g, 3.10 mmol) in ACN (20 mL) was heated under reflux for 18 hours. The reaction mixture was diluted with EtOAc and washed with a saturated aqueous solution of Na2CO3 and brine. The organic phase was dried (MgSO4) and concentrated under vacuum. A portion of the residue (1.0 g, 4.34 mmol) was treated with sarcosine tert-butyl ester hydrochloride (1.57 g, 8.69 mmol) and K2CO3 (2.39 g, 17.4 mmol) in dioxane (5 mL). The resulting mixture was heated at 100° C. for 2 hours, and then concentrated under vacuum. The residue was dissolved in a mixture of DCM and water, and then passed through a hydrophobic frit. The solvent was evaporated under vacuum to afford the title compound (0.952 g, 74%).

Provenance & Evidence