2'-Methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → HCID 66677738, compound

Participants

Reaction Steps

Tert-butyl N-(2-chloro-5-{5-[2′-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate was prepared following the general procedure 3 starting from Intermediate 5 and Intermediate 60. It was hydrolyzed following general procedure 8 to afford the title compound as a white powder. 1H NMR (DMSO-d6, 300 MHz) δ 8.53 (m, 3H), 8.22 (m, 2H), 7.84 (d, J=8.3 Hz, 1H), 7.69 (d, J=8.0 Hz, 1H), 7.43-7.33 (m, 2H), 7.29 (m, 1H), 7.17 (m, 1H), 4.59 (m, 2H), 4.17 (m, 2H), 2.81 (s, 3H), 2.02 (s, 3H). LC/MS (Method B): 516.0 (M+H)+, 514.1 (M−H)−. HPLC (Method A) Rt 4.39 min (Purity: 99.6%).

Provenance & Evidence