HCID 68313441, compound → HCID 68313537, compound

Participants

Reaction Steps

A solution of (1S,3R)-3-phenylcyclopentanamine (second eluting diastereomer from Example 15B, 106 mg, 0.657 mmol) and 1,1,1-trifluoroethanol (20 mL) was added to 5% Rh/Al2O3 (42.4 mg) in a 50 mL pressure bottle. The reaction was heated for 16 hours under 30 psi hydrogen pressure and at 50° C. The mixture was filtered through a nylon membrane, washing with EtOH (50 mL). The solution was concentrated to provide the title compound (77 mg, 70%). MS (DCI) m/z 168 (M+H)+.

Provenance & Evidence