反应详情

A mixture of (3-bromophenyl)hydroxyacetic acid (20 g) and ortho-phenylenediamine (9.36 g) in 5N aqueous hydrochloric solution (100 mL) is heated under reflux for 4 h and cooled back to room temperature. The precipitate is separated by filtration, rinsed with acetonitrile and dried under vacuum with phosphorus pentoxyde et give 1H-benzimidazol-2-yl(3-bromophenyl)methanol as a white crystalline solid used without further purification.

1. temperatureis heated
2. temperatureunder reflux for 4 h
3. customThe precipitate is separated by filtration
4. washrinsed with acetonitrile
5. dry with materialdried under vacuum with phosphorus pentoxyde et