Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalate | HCID 71081 | — |
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 66835995 | HCID 66835995 | — |
| Catalyst | (Pentamethylcyclopentadienyl)iridium(III) chloride dimer | HCID 76030743 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66835975 | HCID 66835975 | — |
Reaction Steps
A mixture of 4-amino-1-methylpiperidine (0.23 g), benzothiazol-2-yl(3-butoxyphenyl)methanol (0.63 g), sodium hydrogenocarbonate (2 mg) and dichloro(pentamethylcyclopentadienyl)iridium(III) dimer (8 mg) in toluene (3 mL) is heated in an autoclave at 110-120° C. for 66 hours. The mixture is purified by chromatography over silica gel (eluant dichloromethane/methanol:98/2) to give the crude base, which is transformed to the oxalate in acetone to give [benzothiazol-2-yl(3-butoxyphenyl)methyl](1-methylpiperidin-4-yl)amine oxalate melting at 176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08802664B2 |
|---|
| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-0a7fd8a58e03413fa622de8ae4b222d8 |
|---|
| Source note | uspto-grants-2014_08 |
|---|
