反应详情

A mixture of (3-bromophenyl)hydroxyacetic acid (809 mg) and 4,5-difluoro-ortho-phenylenediamine (500 mg) in 5N aqueous hydrochloric solution (2 mL) is heated under reflux for 15 h and cooled back to room temperature. The mixture is basified with concentrated sodium hydroxide and extracted with ethyl acetate. The organic phase is then dried over magnesium sulfate and concentrated under reduced pressure. The residue is purified by trituration in dichloromethane to afford the pure 3-bromophenyl(5,6-difluoro-1H-benzimidazol-2-yl)methanol.

1. temperatureis heated
2. temperatureunder reflux for 15 h
3. extractionextracted with ethyl acetate
4. dry with materialThe organic phase is then dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue is purified by trituration in dichloromethane